Clinical Trials for the Newly Diagnosed Child with DIPG
A review of www.clinicaltrials.gov was done on October 20, 2011 to identify which therapeutic trials are currently listed as open for the newly diagnosed child with DIPG. The following is information on the ten (10) listed trials that were listed as accruing patients as well as one vaccine trial that is yet to open. Clinicaltrials.gov seems to be often not be up to date on trial status. If you have interest or questions it might be wise to contact the primary investigator. Contact information is listed at the bottom of each clinical trial site. Most US clinical trials for DIPG can be found with the key word "pontine glioma" but some are still listed under "brainstem glioma".
*Note- many, if not most clinical trials will not allow you to enter a trial if you have already started treatment.
This information was taken from http://www.dipg.blogspot.com
|Study Name||Interventions||Ages||Location||Study Contact||Phone||Verified|
|PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma||DRUG: Crenolanib||18 mths-21 yrs||St Jude (Memphis, TN)||Cynthia Wetmore||901-595-6275||July 2011|
|Molecularly Determined Treatment of Diffuse Intrinsic Pontine Glioma||DRUG: Bevacizumab
|3-18 yrs||when open up to 20 locations- only Boston open on 10/20/11||Mark Kieran||617-632-4907||Sept 2011|
|Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas|| DRUG: Lenalidomide
RADIATION: Radiation Therapy
|1-18 yrs||NIH (Bethesda, MD)||NCI Referral Office||1-888-NCI-1937||July 2011|
|A Study of Bevacizumab Therapy in Patients With Newly Diagnosed High-Grade Gliomas and Diffuse Intrinsic Pontine Glioma||DRUG: Temozolomide
|3-30 yrs||Cincinnati and Chicago||Rebecca Turner, MS, CCRP||513-636-2799||July 2011|
|Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma||DRUG: Cilengitide dose escalation
Radiation: Concomitant radiotherapy
BIOLOGICAL: Exploratory investigation
|6 mths-21 yrs||France|| Pierre LEBLOND, MD
Yvette VENDEL, Sponsor CRA
| (33)3 20 29 59 56
(33)3 20 29 59 40
|Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic Pontine Gliomas||BIOLOGICAL: Rindopepimut||3-18 yrs||Stanford (Palo Alto, CA)||Paul Fisher, MD||650-497-8953||July 2011|
|Vorinostat and Radiation Therapy Followed By Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Pontine Glioma||DRUG: Vorinostat
RADIATION: 3-dimensional conformal radiation therapy
RADIATION: intensity-modulated radiation therapy
|3-21 yrs||COG trial- Multiple Locations||
|Pilot Study of Glioma Associated Antigen Vaccines in Conjunction With Poly-ICLC in Pediatric Gliomas||BIOLOGICAL: HLA-A2 restricted synthetic glioma antigen peptides vaccine
DRUG: Poly ICLC
GENETIC: Reverse transcriptase-polymerase chain reaction
OTHER: enzyme-linked immunosorbent assay
OTHER: flow cytometry
OTHER: immunohistochemisty staining method
OTHER: laboratory biomarker analysis
|19 mths–20 yrs||Pittsburgh, PA||Angela Krol, BSN||412-692-8047||May 2010|
|External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas||OTHER: cetuximab in conjunction with external beam radiation therapy, followed by cetuximab and irinotecan||3-21 yrs||Multiple Locations|| Ira Dunkel, MD
Tanya Trippett, MD
|Valproic Acid and Radiation Followed by Maintenance Valproic Acid and Bevacizumab in Children With High Grade Gliomas|| DRUG: Valproic acid
Radiation: Radiation therapy
|3-21 yrs||POETIC study- several locations|| Jack Su, MD
Susan Blaney, MD
|Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Glioma (Not Yet Open)|| BIOLOGICAL: Brain tumor initiating cells
|3-25 yrs||Minneapolis, MN|| Christopher Moertel, MD
Tambra Dahlheimer, RN
|Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy||RADIATION: Radioactive iodine-labeled monoclonal antibody 8H9||3-21 yrs||New York & Maryland|| Mark Souweidane, MD
Ira Dunkel, MD
|Phase I/II Study of ABT-888 and Radiation, Followed by ABT-888 and Temozolomide, in Children With Newly Diagnosed Diffuse Pontine Gliomas (PBTC-033)|| DRUG:
ABT-888 Dose Level-1
ABT-888 Dose Level-2
ABT-888 Dose Level-3
ABT-888 Dose Level-4
ABT-888 Dose Level-5
|Up to 21 Years||Multiple Locations|| Patricia A Baxter, M.D.
Jack Su, M.D
Finding Clinical Trials
The good news is that parents can search for clinical trials themselves. From the synopsis of the trial, parents can review the inclusion/exclusion criteria, find where the trial is being offered and contact information of the investigators. For completed studies, publications citations are included.
The bad news is that there is no one place to easily search for clinical trials. Each site has its own advantages and disadvantages. Here are some of the most useful sites...
Clincaltrials.gov is service of the NIH which registers federally and privately supported clinical trials in the US and around the world. There are over 56,000 trial listings including 155 countries. One of the greatest advantages is that the site is the ability to search by keywords. Examples of keywords include pontine glioma, brainstem glioma, intrinsic glioma and recurrent solid tumor. For more detailed help on basic and advanced searches - Help for Searching ClinicalTrials.gov
The National Cancer Institute has a listing of over 6,000 clinical trials. One of the features allows one to search specifically for trials under brain tumor, child, brainstem glioma. One can also search location through a zip code.
The primary objective of the Pediatric Brain Tumor Consortium is to rapidly conduct phase 1 and 2 clinical evaluations of new therapeutic drugs, intrathecal agents, delivery technologies, biological therapies, and radiation treatment strategies in children through 21 years of age with primary CNS tumors. The PBTC includes nine leading academic institutions with extensive experience in the design and management of childhood cancer clinical trials for children with brain tumors. Another objective of the PBTC is to develop and coordinate innovative neuroimaging techniques on a consortium-wide basis. Open and closed protocols are listed on this table. PI (primary investigator) contact information and a parent summary are available for enrolling studies.
VirtualTrials.com is a private brain tumor site run through The Musella Foundation. Chose the top button to find a drop down menu to ‘Find a Treatment’. Two other very helpful pages on this site are:
Brain Tumor Center (centers that do more than 50 brain tumors a year and some will provide free reviews of MRIs)
Often individual hospital will have listing of clinical trials that are going on at their institution. You can search specific hospitals for this information as well.
Understanding Clinical Trials
The Clinical Trial Process by Larry Kun MD for the Pediatric Brain Tumor Foundation of the US defines and examines the clinical trials process, providing parents with a basic understanding of the steps involved in participating in a clinical trial.
Educational Materials About Clinical Trials
This site contains multiple informational articles on various aspects of clinical trials.
This information was taken from http://www.justonemoreday.org/TreatingPontineGliomas/ClinicalTrials.html